Therapeutic Delivery of miR-148a Suppresses Ventricular Dilation in Heart Failure
نویسندگان
چکیده
منابع مشابه
Surgical ventricular restoration in the treatment of congestive heart failure due to post-infarction ventricular dilation.
OBJECTIVES The purpose of this study was to test how surgical ventricular restoration (SVR) affects early and late survival in a registry of 1,198 post-anterior infarction congestive heart failure (CHF) patients treated by the international Reconstructive Endoventricular Surgery returning Torsion Original Radius Elliptical shape to the left ventricle (RESTORE)team. BACKGROUND Congestive heart...
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MicroRNAs (miRNAs) are highly conserved noncoding RNAs of about 19-25 nucleotides. Through specifically pairing with complementary sites in 3' untranslated regions (UTRs) of target mRNAs, they mediate post-transcriptional silencing. MicroRNAs have been implicated in many physiological processes including proliferation, differentiation, development, apoptosis, and metabolism. In recent years man...
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1 showed miR-25 to reduce levels of rco/endoplasmic reticulum calcium-ATPase (SERCA) 2a during heart failure, whereas therapeutic inhibition of this microRNA (miRNA) was able to reverse pre-established heart failure in a mouse model of pressure overload. Although these data suggest that miR-25 might be a drug target for the treatment of heart failure, further in vivo analysis is required before...
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Jing Zhang E-mail: [email protected] Zheng-zhou Ying E-mail: [email protected] Zhong-lin Tang Corresponding author. Fax/ Tel: +86 01062813822 Email addresses: [email protected] Liang-qi Long Co-corresponding author E-mail: [email protected] Kui Li E-mail: [email protected] To whom correspondence should be addressed: Zhong-lin Tang, Ph.D, Department of Gen...
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MicroRNAs are small non-coding RNAs that physiologically modulate proteins expression, and regulate numerous cellular mechanisms. Alteration of microRNA expression has been described in cancer and is associated to tumor initiation and progression. The microRNA 148a (miR-148a) is frequently down-regulated in cancer. We previously demonstrated that its down-regulation by DNA hypermethylation is a...
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ژورنال
عنوان ژورنال: Molecular Therapy
سال: 2019
ISSN: 1525-0016
DOI: 10.1016/j.ymthe.2018.11.011